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Graduate Faculty Research Interests
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Faculty Research Interests

Bruce Elliott, PhD
Bruce Elliott

RESEARCH OVERVIEW

“Growth factor and cell adhesion signaling in breast cancer metastasis: potential targets for predictive oncology

Stromal-tumour interactions play key roles in breast cancer metastasis. We have demonstrated a novel Src/Stat3 pathway that regulates an autocrine hepatocyte growth factor (HGF) loop in invasive breast carcinomas.  This involves a unique interaction of the Src kinase with the membrane cytoskeleton crosslinker, ezrin.  This in turn regulates HGF receptor (Met) activation and cancer cell invasion. The effects of pharmacological and genetic inhibitors are being studied in animal tumour engraftment models, and candidate predictive biomarkers will be validated in a human breast cancer cohort.

 

 

CONTACT

Tel: (613) 533-2825
Fax: (613) 533-6830
Email:elliottb (at) queensu.ca
Office: Botterell Hall A307


LABS

> Labs

PUBLICATIONS

> Publications and link to PUBMED


 

 

 

 

 
 
Page Last Updated: 2013 June 11