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News Archive

Queen's researchers benefit from moustache fundraiser

2014 July 16 From: http://http://www.queensu.ca/news/articles/queens-researchers-benefit-moustache-fundraiser

2014-07-15 By Rosie Hales, Communications Officer

A national cancer research collaboration that includes two members from Queen’s has been awarded the $5 million 2014 Movember Team Grant from Prostate Cancer Canada (PCC). David Berman and Paul Park, both from the Department of Pathology and Molecular Medicine, will receive funding as part of the Prostate Cancer Program Project in Rapid Development of Novel Diagnostic Markers for Early Prostate Cancer (PRONTO). PCC identified the research team as poised to make the greatest impact in prostate cancer research. The grant is awarded by PCC and funded by the Movember Foundation, a global charity that relies on the fundraising efforts of men collecting pledges as they grow moustaches every November. PRONTO aims to determine the type of treatment needed when men are diagnosed with prostate cancer. “Being a part of the PRONTO team provides me with a rare opportunity to participate in a large scale biomarker development project from discovery to clinical validation,” says Dr. Park. “The interactions fostered within this multi-institution, trans-disciplinary team will have a big impact in establishing my research career in this field. The funds provided by this grant will be used to support a post-doctoral trainee in my lab, and also to help establish one of the core components of this project here on Queen’s campus.” Fewer than half of diagnosed prostate cancers are harmful and men newly diagnosed with the disease face an array of options and possible side effects. “If we could better separate harmful and harmless prostate cancers, we could help patients and their doctors make clearer choices. With funding from Movember and Prostate Cancer Canada our team will develop new and better tests for this purpose,” says Dr. Berman. “For members of my laboratory and me, this is an unprecedented opportunity to work with experts in a variety of critically important areas to do something important for patients. We are extremely grateful to Movember, Prostate Cancer Canada, and all of the donors and volunteers who have made this work possible.” The team is led by John Bartlett of the Ontario Institute for Cancer Research and the research team is made up of 14 researchers from across Canada. Follow these links for more information on Prostate Cancer Canada and Movember Canada.

berman2-2014july

Cancer grading gets an upgrade

2014 July 14 From: http://www.queensu.ca/news/articles/cancer-grading-gets-upgrade

2014-07-11 By Rosie Hales, Communications Officer

Prostate cancer is the second most commonly diagnosed cancer among Canadian men but only about half of these cancers grow rapidly enough to require treatment.

However, determining which prostate cancers need to be treated can be tricky because it's hard to predict through biopsy which cancers will eventually become harmful. In fact, because biopsies often do not yield accurate information, between a third and half of patients initially diagnosed with harmless prostate cancers are likely to be "upgraded" to potentially harmful cancers within a year or two of diagnosis.

A research team led by Dr. David Berman, a professor in the Department of Pathology and Molecular Medicine at Queen's, and Dr. Tamara Lotan from Johns Hopkins University discovered that the decline of a specific protein within a tumour could help identify the tumours requiring treatment.

"We have shown that a tumour-suppressing protein called phosphatase and tensin homolog, or PTEN, is lost most frequently in prostate tumours that will become harmful and require treatment," says Dr. Berman. "The team from Johns Hopkins has done a terrific job of making this test more reliable and valid and applicable to prostate cancer and to other forms of cancer."

berman-2014july

Interim Head of the Department of Pathology & Molecular Medicine

2014 June 26

On behalf of Dean Richard Reznick, I am writing to inform you that Dr. Lois Shepherd has accepted Provost Alan Harrison’s offer of appointment as Interim Head of the Department of Pathology & Molecular Medicine at Queen’s University for the period July 1, 2014 to June 30, 2015.

The Boards of Hotel Dieu Hospital, Kingston General Hospital and Providence Care have also approved the recommendation that Dr. Shepherd be appointed as Interim Head of Pathology & Molecular Medicine at their institutions for concurrent terms.

Gail L. Knutson Senior Staffing Officer Faculty of Health Sciences

interimhead2014june

Pathology Research Day 2014

2014 May 26

Thank you all for your participation in yesterday’s departmental research day!

Congratulations again to:

Dr. Gulisa Turashvili for Best Talk/Poster Presentation by a Resident

&

Dr. Stacy Visser-Grieve for Best Talk/Poster Presentation by a Post Doctoral Fellow.

researchday2014may

New hope for breast cancer patients

2014 May 14

From: https://www.queensu.ca/news/articles/ new-hope-breast-cancer-patients
By Anne Craig, Communications Officer

Queen's University researcher Xiaolong Yang has discovered the key to understanding how breast cancer patients become resistant to chemotherapy. This discovery could lead to more successful breast cancer treatment.

"We have identified a protein that may be critical in causing the resistance of breast cancer cells to antitubulin drugs, a group of chemotherapeutic drugs commonly used for the treatment of breast and lung cancer," explains Dr. Yang, an associate professor in the Department of Pathology and Molecular Medicine.

The research group led by Dr. Yang has discovered that antitubulin drugs kill breast cancer cells by inactivating a protein called YAP, which is critical for protecting cancer cells from drug-induced cell death. However, when the YAP protein becomes immune to drug-triggered inactivation, it can protect cancer cells from dying.

This discovery suggests that the YAP protein status can be used as a marker in predicting antitubulin drug response in patients which could lead to more effective chemotherapy.

Dr. Yang's research team including PhD candidate Yulei Zhao, Prem Khanal, a Terry Fox Transdisciplinary Postdoc Fellow, and Paul Savage (Artsci'11), currently an MD/PhD student at McGill University, collaborated on the research with Drs. Yi-Min She and Terry Cyr at Health Canada.

This research, which was funded by the Canadian Breast Cancer Foundation, was published online in the journal Cancer Research.

yang2014may

Dr. David Rimm recently visited the Department of Pathology and Molecular Medicine.

2014 April 11

Dr. David Rimm (Professor at Yale University) recently visited the Department of Pathology and Molecular Medicine, and spoke in the Queen’s Cancer Research Institute Seminar Series on “Quantitative In Situ Measurement of Biomolecules for Companion Diagnostics”. Dr. Rimm has pioneered the development of new quantitative approaches to biomarker assessment in pathology, and their use to classify tumors by prognosis or predict response to cancer therapy. Dr. Rimm's open approach to collaboration and sharing of resources and technology expertise was much appreciated by the translational researchers in our department and the Queen’s Cancer Research Institute.

rimm2014apr

Canadian Medical Hall of Fame inductee

2014 May 08

Dr. Adolfo de Bold a recent inductee into the Canadian Medical Hall of Fame, visited the Department on Tuesday, April 22nd, 2014. He met with students and faculty and presented a seminar entitled: "The Discovery of the Endocrine Heart: A Paradigm Shift in Basic and Clinical Cardiology"

Dr. de Bold and 5 colleagues were inducted into the Canadian Medical Hall of Fame at a recent ceremony hosted by the Queen's Faculty of Health Sciences on Thursday, April 24, 2014.

Several Faculty, residents and students attended the Canadian Medical Hall of Fame induction ceremony on Thursday, April 24, 2014.

debold2014maymar

Queen's Pathology Resident Research at USCAP 2014

2014 April 10

Queen's Pathology and Molecular Medicine was well represented in early March 2014 at the 103rd Annual Meeting of the United States and Canadian Academy of Pathology (USCAP) in beautiful San Diego, California.

In the Autopsy Session on Monday, March 3, Dr. Gulisa Turashvili presented her poster titled "Array-CGH Study of Autopsy Specimens: A Search for Tissue-Specific copy Number Changes".

On Tuesday, March 4, Dr. Charles Leduc presented a poster at the Breast Pathology session titled "Concurrent Molecular Targeting of Raf and Mek in Triple Negative Breast Cancer".

Dr. Ami Wang presented her poster titled "Reduced Membranous Expression of EpCAM-ICD Correlates with Poor Patient Outcome in Primary Colorectal Adenocarcinoma" at the Gastrointestinal Pathology session on Tuesday, March 4.

uscap2014mar

The 7th M. Daria Haust Visiting Lecturer

Tuesday 2014 May 20, 4pm, Richardson Lab Amphitheatre

Dr. Murray W. Huff, PhD (Professor of Medicine and Biochemistry, University of Western Ontario, Director, Vascular Biology Research Group, Robarts Research Institute, London Ontario.

"Halting the Progression of Atherosclerosis: the Impact of PPAR Delta Activation"

Posted: 2014 April 10

haust2014april.htm

The Local View with Ted Hsu: Breast Cancer Action Kingston

2014 March 21

Sue Davies (President, Breast Cancer Action Kingston) and Dr. Sandip SenGupta (Professor, Pathology and Molecular Medicine) appeared on "The Local View with Ted Hsu", a local television production in Kingston.

The show will air in May 2014: see this Youtube link: http://youtu.be/8o-7Yo2rlCk

Background: Breast Cancer Action Kingston (BCAK) is a survivor-led, independent, non-profit charitable organization. They are committed to research and advocacy directed towards prevention, early diagnosis and treatment, educating women, men, the public and physicians about the importance of breast self-examination and the benefits of early detection and to providing support for patients, survivors and their families as they cope emotionally and physically with breast cancer.

bcak2014mar

Professor made an honorary professor at Chinese university

2014 January 22
From http://www.queensu.ca/news/articles/professor-made-honorary-professor-chinese-university

by Wanda Praamsma, Communications Officer

Professor Susan Cole says she's always been internationally inclined since her first school trip to Japan at age 15. She loves to travel, enjoys bringing foreign students and postdoctoral fellows into her cancer research lab, and is involved in a handful of research collaborations with universities and clinics around the world.

"The beauty of biomedical science is that it is international," says Dr. Cole, who teaches in the departments of Pathology and Molecular Medicine, and Biomedical and Molecular Sciences, and is a Tier 1 Canada Research Chair in Cancer Biology and Bracken Chair in Genetics & Molecular Medicine. "Over the years, it's been wonderful to have many different countries represented in the lab and see the connections and collaborations that emerge from the relationships."

cole2014jan

Six Canadian medical heroes will be inducted into The Canadian Medical Hall of Fame (CMHF)

Dean On Campus, 2013 September 27

Tuesday was a big day at Queen’s University. Principal and vice-chancellor, Daniel Woolf announced the names of six Canadian medical heroes who will be inducted into The Canadian Medical Hall of Fame (CMHF) on April 24, 2014. For the first time, Queen’s University and Kingston will host this national event at the Rogers KRock Centre.

As co-chairs of the 2014 Induction Committee, vice-Principal (Advancement) Tom Harris, and I are delighted about the exceptional nominees that we will honour next April (and one in particular – be sure to read to the end of the list):

Dr. Adolfo de Bold, an alumnus of Queen’s University who completed his graduate studies here. He received his Masters of Science 1971 and PhD in 1973 in experimental pathology. Dr. de Bold was also an esteemed faculty member in Queen’s Department of Pathology. In 1981, at a lab in Hotel Dieu Hospital, he discovered the cardiac hormone atrial natriuretic factor (ANF). This is considered one of the most important contributions to cardiovascular discoveries of the last half-century. For the first time we understood that the heart is more than a simple muscle – but a complex endocrinologic organ.

Dr. de Bold attended the announcement with his wife Dr. Mercedes Lina deBold (who also has a PhD from Queen’s). He spoke very fondly of his time in Kingston. His words illustrated the value of living, learning and working in at such a close-knit campus and community. He told us how he studied and then taught across the street in Botterell Hall, how all five of their children we born a block away at KGH, and how only a few blocks away he made a game-changing breakthrough at Hotel Dieu.

What I didn’t know beforehand, is Dr. De Bold took a big leap of faith in coming to Queen’s. In 1968, after meeting a Queen’s faculty member in Argentina, he decided to move (9,000km!) to Kingston with only a one-year contract as a research assistant. He enjoyed his work here as an R.A. so much that, well…the rest is history. To wrap up this lengthy post, I would like to thank Principal Woolf and the Honourable Senator Hugh Segal who are the honourary co-chairs for the 2014 Induction. My very sincere thanks go out to the volunteers who are working very hard to make the 2014 ceremony a showcase for our community in the national spotlight. It will be an inspiring event and encourage all Kingstonians to consider attending, sponsor a student or best of all; purchase a table. You can find out more directly from The Canadian Medical Hall of Fame, 519.488.2003, or email: cmhf@cdnmedhall.org.

Posted: 2013 September 27

debold2013sept.htm

Three faculty members become Fellows of the Canadian Academy of Health Sciences

By Rosie Hales, 2013 September 19

Three Queen's professors and respected researchers have been formally inducted as fellows of the Canadian Academy of Health Sciences (CAHS).

Roger Deeley (Pathology and Molecular Medicine), Jacalyn Duffin (Medicine, Philosophy, History, Nursing, Education), and Elizabeth Eisenhauer (Oncology) were chosen based on their demonstrated leadership, creativity, competence and commitment to the health sciences.

Dr. Deeley is the Vice-Dean of Research for the Faculty of Health Sciences, Director of the Queen's Cancer Research Institute, and a professor of pathology & molecular medicine, oncology, and biomedical & molecular sciences. His research focus on multidrug resistance proteins (MRP) has been widely recognized as a major contribution to understanding the causes of resistance to cancer chemotherapy.

"I'm very honoured to have been elected as a Fellow of the Academy and I look forward to participating in the activities of the Academy in its support and promotion of health research in Canada," says Dr. Deeley.

Posted: 2013 September 23

cahs2013sept.htm

Record number of Queen's professors elected to Royal Society of Canada

By Anita Jansman 2013 September 06
From https://www.queensu.ca/news/articles/record-number-queens-professors-elected-royal-society-canada

Seven Queen's University professors were named among the newest fellows of the Royal Society of Canada (RSC) today, more than in any other single year.

"It is remarkable in a university of our medium size to have seven distinguished faculty members elected to the Royal Society of Canada in one year. Each of these individuals has made important contributions to their fields, and I congratulate them on this well-deserved honour," says Principal Daniel Woolf, who currently serves on the RSC Executive Committee. "Moreover, fellowship in the three academies of the RSC is a much more meaningful and enduring measure of Queen's University's individual and collective achievements in research than are rankings exercises, which are too easily distorted by size of institution."

David Lillicrap (Pathology and Molecular Medicine) is an internationally-renowned researcher focused on the genetic basis of hemophilia and von Willebrand disease (VWD). His work has led to innovative strategies for the diagnosis and treatment of the world's most commonly-inherited bleeding diseases. Lillicrap's novel findings, now being applied to clinical care worldwide, are improving the quality of life for patients with inherited bleeding disorders.

The Royal Society of Canada was established under an Act of Parliament in 1882 as Canada's national academy. It helps promote Canadian research, scholarly accomplishment and advises governments, non-governmental organizations and Canadians on matters of public interest.

Posted: 2013 September 09

royalsociety2013sept.htm

Forensic pathologist brings expertise to Queen's and Kingston

From http://www.queensu.ca/news/articles/forensic-pathologist-brings-expertise-queens-and-kingston

Dr. Kris Cunningham by Anita Jansman

Kris Cunningham is the newest faculty member in the School of Medicine's Department of Pathology and Molecular Medicine. He brings with him a wealth of experience and education to the science of forensic and cardiovascular pathology.

He comes from the University of Toronto, where he was a forensic and cardiovascular pathologist and medical director at the Provincial Forensic Pathology Unit of the Ontario Forensic Pathology Service.

From the unique perspective of forensic pathology, Dr. Cunningham feels he can contribute to the well-being of surviving relatives of patients who have lost their lives to genetic forms of cardiovascular disease.

"It's a sad event when a young person dies of an undiagnosed inherited heart condition. The one thing I can potentially offer to relatives is insight on whether they too carry the mutation. They can be treated and then make important decisions about their own lives such as whether or not to have children," says Dr. Cunningham.

When he began studying medicine, after earning a PhD in biochemistry from Ohio State University, Dr. Cunningham planned to become a cardio specialist. But he changed his mind and chose to study pathology instead.

There has recently been an interest in utilizing the tools of molecular pathology to help answer questions that arise out of postmortem examinations, and Dr. Cunningham feels excited and privileged to be a part of this fascinating area of study. "We're planning to develop a molecular autopsy program here at Queen's" he says.

At Queen's, Dr. Cunningham will teach cardiovascular pathology, forensic pathology and courses in autopsy to medical, graduate and undergraduate students as well as to residents in pathology. He also plans to develop a research programme into sudden cardiac death.

In addition to his academic work at Queen's, Dr. Cunningham has also taken on the role of director of the Kingston Regional Forensic Pathology Unit and the Kingston General Hospital Autopsy Service. In this role, he will provide forensic pathology services to the region and fill a position that has been vacant for years. Needless to say, his arrival has made local and regional law officials relieved and happy.

"All criminally suspicious cases used to be sent to Ottawa or Toronto making it necessary for law enforcement officers to go there. It makes their job easier having someone in Kingston and brings in an expertise locally that can facilitate their investigations," says Dr. Cunningham.

Dr. Cunningham sees a personal benefit to leaving Toronto and moving to Kingston - he no longer has an hour-long commute to get to work. He and his wife, an art historian, are settling into their new home in west-end Kingston with their two young children. They're thrilled to be in such a family-friendly city and look forward to building a new life here.

Posted: 2013 July 22

cunningham2013july.htm

Heart and Stroke funds will help research

From http://www.thewhig.com/2013/06/25/heart-and-stroke-funds-will-help-research

KINGSTON - A commitment by the Heart and Stroke Foundation to fund 19 of Canada's leading research institutions with $300 million over 10 years is a welcome sign of long-term support, but it won't bring any immediate major changes to research in the country, said a researcher at Queen's University, one of the institutions receiving the money.

"There won't be immediate changes, but I think it's a recognition that we have the opportunity to build on what is already a strong base of research with the potential of enhancing and expanding that at Queen's and the other institutions involved," said Dr. David Lillicrap, a professor in the Department of Pathology and Molecular Medicine.

"I think we are all very pleased about this, but we don't expect to see in a few months, or even in one or two years, a major change. It is an evolutionary thing."

Lillicrap said the Heart and Stroke Foundation, the major funder of heart and stroke research in the country, is going through a major reorganization at the moment to strengthen the organization and particularly strengthen funding opportunities for research.

Posted: 2013 June 26

lillicrap2013june.htm

Queen's professor a world leader in vascular disease research

From www.queensu.ca/news/articles/queens-professor-world-leader-vascular-disease-reserach

For the past five years, Queen's University researcher Donald Maurice (Biomedical and Molecular Sciences) (cross appointed to Pathology and Molecular Medicine) has headed the Cardiac, Circulatory and Respiratory (CCR) research program in the Faculty of Health Sciences, a group of more than 30 clinicians and basic scientists who research the prevention, diagnosis and treatment of cardiovascular and respiratory diseases.

Dr. Maurice's laboratory is currently examining the underlying causes of vascular disease by testing the idea that healthy cells carry out their various functions by grouping together proteins required and allowing them to interact within defined compartments.

Dr. Maurice's passion for his research is obvious, and it is accompanied by a strong work ethic, which grew from his roots in northern Ontario and his undergraduate summer experiences as an iron worker. He earned his doctorate at McMaster University under the late Professor Richard Haslam.

Posted: 2013 June 25

maurice2013june.htm

New Appointments within the Department

Effective on or about 2013 July 1st, we have a number of new people associated with the Department:

Primary Appointments:

  • Kristopher Cunningham, MD; Assistant Professor; Director, Kingston Regional Forensic Pathology Unit; Clinical Director, KGH Autopsy Service
  • Prameet Sheth, PhD; Assistant Professor; Clinical Microbiologist
  • Sonal Varma, MD; Assistant Professor

    Cross Appointments:

  • Sam Basta, PhD, Associate Professor
  • Igor Jurisica, PhD; Professor; Computer Science
  • Jagdeep Walia, MBBS; Assistant Professor; Gene Therapy

    Adjunct Appointments:

  • Jian Chen, PhD; Assistant Professor; Proteomics
  • Anna Majury, PhD, DVM; Assistant Professor; Microbiology/Public Health
  • Paul Park, PhD, MD; Assistant Professor
  • Terrence Sills, PhD; Associate Professor; Genomics

    Posted: 2013 June 12

    newfolk2013june.htm

  • Queen's researchers receive $1.3 million in federal funding

    Six Queen's researchers with projects ranging from improving treatment for Parkinson's disease, to preventing work-related injuries are receiving $1.3 million from the Canada Foundation for Innovation (CFI). "The CFI, through the Leaders Opportunity Fund (LOF), has provided us with an excellent mechanism for attracting and retaining top-flight researchers," says Vice-Principal (Research) Steven Liss. "As a result of this competition, six Queen's researchers will receive the funding required to develop innovative infrastructure that will provide the enriched research training environments necessary for leading-edge research. "

    Michael Rauh (Pathology and Molecular Medicine) - Dr. Rauh will explore next-generation technologies that will allow earlier detection of blood cancer which causes debilitating and life-threatening fatigue, bleeding, infections and can progress to leukemia. The funding is being used to create a blood cancer research laboratory at Queen's.

    Dr. Michael Rauh's Leaders Opportunity Fund Project, "A Translational Research Pipeline for Personalized Diagnostics in Myelodysplastic Syndromes" was for $206,000.

    Posted: 2013 June 10

    rauh2013june.htm

    2013 PAIRO Excellence in Clinical Teaching Award

    2013 March 15

    Dr. John Rossiter was chosen as one of the recipients of the 2013 PAIRO (Professional Association of Internes and Residents of Ontario) Excellense in Clinical Teaching Award for Queen's University.

    The Award comes with a $1000 donation to the award winners charity of choice.

    Susan Cole is the first-ever Researcher-in-Residence at PARTEQ Innovations

    2013 January 31

    Susan Cole is the first-ever Researcher-in-Residence at PARTEQ Innovations, the technology transfer arm of Queen’s University. The former Queen’s Deputy Provost and PARTEQ board member will help mentor and assist researchers in the life sciences who are considering protecting their discoveries for the purpose of commercialization.

    Dr. Cole will be working closely with Michael Wells, manager of commercial development in life sciences at PARTEQ.

    “As an active researcher at the ‘front lines,’ I’m in a unique position to keep an eye and ear out for new and interesting ideas and suggest that researchers talk to PARTEQ,” says Dr. Cole, who holds the Canada Research Chair in Cancer Biology and the Bracken Chair in Genetics and Molecular Medicine. “I hope I can also suggest ways to help researchers avoid premature public disclosure that would compromise their ability to protect the potential intellectual property associated with their discoveries.”

    Dr. Cole co-invented PARTEQ’s most-licensed technology with Roger Deeley, Vice-Dean Research, Queen’s Health Sciences/Vice-President, Health Sciences Research, Kingston General Hospital. The technology provides a gene coding for multidrug resistance protein (MRP). This discovery has been instrumental in advancing scientists’ understanding of drug resistance in tumors. It has been licensed to more than 30 companies worldwide and their original research paper on MRP has been cited more than 2,500 times since 1992.

    cole2013jan

    David Murray Robertson, MD

    2012 October 17

    ROBERTSON, David Murray, MD - At home on Monday, October 15, 2012 in his 81st year. Beloved husband of Alice, survived by daughter Ellen and her husband James, daughter Barbara and son Douglas and his wife Annette and grandchildren Emily, Elizabeth, Vanessa and Patrick, Predeceased by parents Ellen and George Robertson of Weyburn, Sask., and brother Donald.

    A 1955 graduate of Queen's University, he had a distinguished 30 year career at Queen's University and KGH as an academic neuropathologist. During his career he established the Neuropathology Division of the Department of Pathology as a successful and internationally recognized academic unit. He enjoyed many years as a recreational pilot and spent time in retirement on woodworking projects and at the family cottage.

    A private service will be held at a later date. A special thank you to Barbara Fuller, MD, and the caring staff of CCAC, The Red Cross and Premier Homecare Services.

    For those wishing, donations to U.H.K.F. - KGH department of Pathology would be appreciated

    robertson2012oct

    KGH researchers working to develop new prostate cancer test

    2012 Aug 21

    Men with prostate cancer could soon know precisely how serious their disease is - and how aggressively to treat it - the moment they are diagnosed, thanks to a new team of researchers at KGH.

    "We hope to create a test so accurate that patients don't need to consider surgery or radiation unless it's really needed," says Jeremy Squire, Research Chair in Molecular Pathology at KGH and Professor in the Department of Pathology and Molecular Medicine at Queen's University.

    Squire heads up the research team along with recent recruits Paul Park and Paulo Nuin, both adjunct assistant professors. As members of the newly formed Canadian Prostate Cancer Biomarker Network (CPCBN), they are joining investigators from across the country who are working to create a test that could augment - or altogether replace - the Prostate Specific Antigen (PSA) test currently used.

    And thanks to a recent $4 million funding boost to the network via the Terry Fox Research Institute and the Canadian Partnership Against Cancer, a new test could be close at hand.

    Adding further momentum, Nuin and Park have secured two grants amounting to $300,000 from the Prostate Cancer Canada Pilot Grants for Young Investigators. The funding will go a long way to "creating significant research discoveries at KGH", says Squire.

    So why is a new test needed? Squire says it comes down to the PSA test’s sensitivity. "The PSA test will detect even the most benign cases," he says. "That can lead to over-treatment, which is a problem especially in the case of elderly men in whom treatment could cause more damage than the cancer."

    Unlike the PSA blood test, the KGH team plan to develop a test that examines tissue from the tumour itself. "Our test would give a precise risk. So, in many cases, doctors would be able to tell patients that they’ll be fine to live their life without undergoing further treatment," says Squire.

    As part of CPCBN, researchers will share clinical samples acquired at KGH with members across the country.

    Their inclusion is an important step for KGH, says Squire.

    "I've spent three years to ensure we were part of this," he says. "With KGH’s access to a large cohort across Canada, we can design studies that will have national prominence statistically." The team is optimistic about how quickly they can develop the test. "If you’d asked me before, I would have said within five to ten years," says Squire. "Now, I’d say five."

    That timeframe is paramount because aging baby boomers will need the test the most, he says. "Our aging population is a great concern. But we hope to move from discovery to application very quickly."

    Above all, the new biomarker test would allow physicians to create a truly patient-centered treatment plan. "Treatment could be tailored to the type of tumour a patient has while taking into consideration his age," says Squire. "Now that’s personalized medicine!"

    squireparknuin2012aug.htm

    Dr. M. Daria Haust was awarded the Queen Elizabeth II Diamond Jubilee Medal

    2012 August 14

    Dr. M. Daria Haust was awarded the Queen Elizabeth II Diamond Jubilee Medal of the Governor General of Canada at a special presentation ceremony of the Diamond Jubilee Gala, Roy Thomson Hall, Toronto, on June 18th, 2012.

    A new commemorative medal was created to mark the 2012 celebrations of the 60th anniversary of Her Majesty Queen Elizabeth II's accession to the Throne as Queen of Canada. The Queen Elizabeth II Diamond Jubilee Medal is a tangible way for Canada to honour Her Majesty for her service to this country. At the same time, it serves to honour significant contributions and achievements by Canadians.

    During the year of celebrations, 60 000 deserving Canadians will be recognized.

    The Chancellery of Honours, as part of the Office of the Secretary to the Governor General, administers the Queen Elizabeth II Diamond Jubilee Medal program.

    haust2012aug

    Dr. David Good

    2012 July 03

    Welcome to new Faculty member Dr. David Good, Hematopathologist, Assistant Professor

    Dr. Good will be taking up residence in Richardson Labs Room 201C.

    good2012jul

    CACB Award for Outstanding Contribution to the Profession of Clinical Biochemistry
    Sponsored by Siemens Healthcare Diagnostics

    2012 June 11

    Dr. Christine Collier, Service Chief for Clinical Chemistry at Kingston General Hospital and consultant Clinical Biochemist at Belleville General Hospital is the 2012 recipient of this award “in recognition of her multitude of accomplishments that have advanced the field of Clinical Biochemistry in Canada in the past 24 years”.

    Dr. Collier’s current service and research interests include cardiac markers, chronic kidney disease and eGFR, protein electrophoresis, testosterone in hypogonadism, and the importance of biological variation and measurement uncertainty in test interpretation. At Queen’s she has been involved in TIPS (Teaching Improvement Project System), PBL and medical school admissions for many years, and she served three years as the Phase II coordinator for undergraduate Medicine. Dr. Collier has been a member of Ontario’s QMPLS General Chemistry Committee, President of the OSCC and Chair of Upstate New York section of the AACC, and on the IATDMCT. She runs the listservs for the CSCC, OSCC and IATDMCT. She helped coordinate implementation of eGFR reporting in Ontario and across Canada, revamped the CSCC CE program into the Professional Development program, and for the last 5 years has co-coordinated the bimonthly CSCC Education Roundtable webinars, which reach 200+ people at 30+ sites.

    Dr. Collier received the CSCC Award for Education Excellence in 2000 and 2004, the Canadian Association of Medical Education’s Certificate of Merit in 2005, the OSCC Award for Outstanding Contribution to Clinical Chemistry in 2006, the CSCC Grant for Leadership and/or Administration in 2007 and 2008, and the Upstate New York AACC Somogyi-Sendroy Award in 2008. She is currently studying part-time for a Masters in Community Health and Epidemiology at Queen’s University.

    collier2012june

    Decreasing Risk of Breast Cancer Recurrence Aided by Good Bone Health

    2012 June 11

    Good bone health may also be a step towards preventing recurrence of breast cancer, according to results from an exploratory study led by the NCIC Clinical Trials Group (NCIC CTG) located at Queen's University.

    "Results of the study suggest that preventing this deterioration in bone health by using commonly-used therapeutics known as bisphosphonates may have an additional positive effect in decreasing the risk of breast cancer recurrence", says Lois Shepherd, Professor in the Department of Pathology and Molecular Medicine at Queen's University, physician coordinator at the NCIC Clinical Trials Group and a pathologist at Kingston General Hospital.

    shepherd2012june

    Dr. Xiaolong Yang has received a three-year research grant from Canadian Breast Cancer Foundation (CBCF)

    2012 May 03

    Dr. Xiaolong Yang has received $449,100 for a three-year research grant from Canadian Breast Cancer Foundation (CBCF) to study the roles of several novel genes in chemotherapeutic drug resistance of breast cancer.

    Breast cancer is the most frequently diagnosed cancer in women worldwide and is responsible for one third of all cancer deaths of women in Canada. One of the difficulties encountered in breast cancer therapy is that breast cancer patients are usually either intrinsically resistant to chemotherapeutic drugs or acquire resistance after initial treatment, which results in cancer recurrent following primary chemotherapy. The research findings from this project will not only has the potential to significantly advance our understanding of the molecular mechanism underlying drug resistance but also has great implication for the future development of novel therapeutic drugs for the successful treatment of drug-resistant breast cancer patients.

    yang2012may

    2012 March 27
    Are you a student looking for a PATH499 or CANC499 supervisor & Lab for 2012-2013? ** Go here to see the list of faculty **, with their research interests and contact information, *possibly* taking 4th year students. Please contact them directly.

    Posted 2012 April 11

    Dr. Stacy Visser-Grieve is on a roll! She recently won a Fellowship Award from the Terry Fox Foundation -CIHR Training Program in Transdisciplinary Cancer Research and now she has won a prestigious Post-Doctoral Fellowship Award from the Canadian Breast Cancer Foundation of $142,500 over three years. These awards will allow her to pursue a project entitled "Identifying substrates of the calpain protease system and elucidating calpain's role in the cancer cell signalling network". This will be carried out in the laboratory of Dr. Peter Greer in the Queen's Cancer Research Institute in the context of his Canadian Institutes of Health Research funded research project investigating calpain proteases as potential therapeutic targets in breast cancer. Stacy's project will include innovative protein structure-function and mass spectrometry-based proteomic methods to identify novel calpain targets, as well as transgenic mouse and cell models to elucidate the molecular roles of calpain in cancer cells. This work will be carried out in collaboration with Drs. Zongchao Jia and Steve Smith.

    Stacy is a recent graduate of the Pathology and Molecular Medicine PhD program where she trained with Dr. Xiaolong Yang and published several outstanding papers on the LATS tumor suppressor. We are delighted that her outstanding potential as a cancer researcher has now been recognized by the CBCF, and that we have the opportunity to see her take the next steps in her development as a future independent breast cancer researcher.

    2012 March 19

    Dr. Surtaj Iram - ABC2012 Young Investigator Award

    Dr. Surtaj Iram, a postdoc in Dr. Susan Cole's laboratory, won a "ABC2012 Young Investigator Award" at the recent Federation of European Biochemical Societies (FEBS) meeting in Innsbruck March 8th!

    This is a very prestigious competitive award because this biannual meeting (4th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins) is the top international meeting in the field. There is a cash prize that accompanied this award. So you can see that Surtaj's success at the recent Resident/Post doc Day is now reflected internationally.

    Roger G. Deeley reappointed Vice-Dean Research in the Faculty of Health Sciences and Vice President Health Sciences Research at Kingston General Hospital

    Posted 2012 February 07

    Roger Deeley has been reappointed as Vice-Dean Research in the Faculty of Health Sciences at Queen's University and Vice President Health Sciences Research at Kingston General Hospital and for the Kingston teaching hospitals for a second five-year term commencing January 1, 2012.

    These appointments are announced by Dr. Alan Harrison, Provost and Vice-Principal (Academic) at Queen's University, and Ms. Leslee Thompson, President and Chief Executive Officer at Kingston General Hospital.

    Following ten years with the National Cancer Institute at the National Institutes of Health in the United States, Dr. Deeley came to Queen's University in 1980. He was promoted to the rank of Professor in 1984 and in 1987 he was appointed as the first holder of the Joseph S. Stauffer Chair and as Director of the Cancer Research Laboratories. He served as Director of the Division of Research for Cancer Care Ontario from 1988 to 2007 and since 2003 he has also been the Director of Queen's Cancer Research Institute. Dr. Deeley has held the joint position of Vice-Dean Research in the Faculty of Health Sciences and Vice President Health Sciences Research at Kingston General Hospital since 2007. Dr. Deeley is a member of the Department of Pathology and Molecular Medicine with cross-appointments in the Department of Biomedical and Molecular Sciences and the Department of Oncology.

    Dr. Deeley has maintained an active, internationally recognized research program that has been continuously funded from sources such as the Canadian Institutes of Health Research, the National Cancer Institute of Canada, the Heart and Stroke Foundation of Ontario, and industry. He has also been responsible for developing a number of major research initiatives, which together with his own research program, have garnered over $32M in funding. Dr. Deeley has extensive experience with research funding agencies and he has been involved in both provincial and national cancer control research agendas. Over the course of his career, Dr. Deeley has published numerous peer-reviewed research papers, reviews and book chapters, and he is also co-inventor on a number of patents related to the discovery of the multi-drug resistance protein, MRP1. Dr. Deeley was co-recipient in 2005 of the Robert L. Noble Prize presented jointly by the National Cancer Institute of Canada and the Canadian Cancer Society, and in 2007 he was the recipient of the National Cancer Institute of Canada's Diamond Jubilee Award for outstanding contributions to cancer research.

    posted: 2012 January 30

    Lung cancer is the most common cancer worldwide, killing 1.2 million people annually. Therefore, identification of genes responsible for lung cancer development is crucial for its successful therapies. Dr. Yang's lab has recently discovered TAZ, a major component of an emerging Hippo signaling pathway, as a novel gene causing lung cancer.

    In this research project, Dr. Yang will further explore how TAZ and other components of the Hippo signaling pathway contribute to lung cancer development and progression using human lung cancer cell lines, mouse model, and clinical cancer patient tissues. The research findings from this research project will finally identified a new pathway critical for lung cancer development and will have great implications for the future diagnosis and therapy of lung cancer.

    Aperio/Spectrum system updated
    2011 May 19

    The Department's Aperio/Spectrum system was massively upgraded and now sports a newer, faster web server along with updated versions of the Spectrum web service. Check it out at http://www.path.queensu.ca/epu/PathLab2/slidescanning/slidescanningservices.htm

    posted: 2011 April 25

    Hundreds of world class researchers have helped KGH carve out a reputation as a national and global leader ion patient-porinted research.
    Everyone will have a chance to learn more about just what they are discovering and creating at our inaugural Research Showcase.
    The Showcase is also a step toward realizing the KGH 2015 strategic goal of cultivating an environment that will help strengthen the hospital's reputation as a hub of patient-oriented clinical research.
    Dr. Jeremy Squire, KGH's first ever Research Chair in Molecular Pathology, will deliver the keynote address, sharing his insights into taking research discoveries from the prostate cancer genome into clinical practice. The showcase will also include tours of research facilities and oral and poster presentations from dozens of KGH research teams. The free event is open to all KGH staff, members of the regional research community and the general public.

    9:00-5:30 KGH Research Showcase Queen's Etherington Hall & Richardson Amphitheatre
    9:00 Keynote Speaker: Dr. Jeremy Squire "Taking research discoveries from the prostate cancer genome into clinical practice." Etherington Hall Auditorium

    Transdisciplinary Training Program - Cancer Research Institute
    2011 March 04
    For PhD candidates Jess Cockburn and Vikki Ho, the reasons for taking an interdisciplinary approach to research are clear. “Aside from the innate fact that this is where all research is going, I think everyone is starting to realize that we can learn a lot more if we work together in a group setting,” explains Cockburn. “I think we’re more efficient and resourceful working as a team,” adds Ho.

    Both Ho and Cockburn are part of the the Queen’s University Terry Fox Foundation Traning Program in Transdisciplinary Cancer Research in Canada, housed within the university’s Cancer Research Institute. The program gives graduate students and post-doctoral fellows a chance to work with researchers in different disciplines within cancer research. Cockburn explains that while the program is open to anyone doing cancer research, “you have to demonstrate that your research is truly transdisciplinary.” {MORE]...

    Researchers awarded $850,000 for five projects

    2011 January 21

    Queen's University researchers have received $848,828 from the Canadian Foundation for Innovation (CFI) for five projects that range from studying how drugs are dispersed through the body to finding a better way to assess the condition of Canada's deteriorating infrastructure.

    Susan Cole (Pathology and Molecular Medicine) leads a team that received $400,000 to purchase a state-of-the-art mass spectrometer that will be housed in Chernoff Hall and managed by the newly formed Queen's Mass Spectrometry and Proteomics Unit (QMSPU). Civil Engineering professor Neil Hoult.

    "We will be purchasing a machine that will be the envy of other universities and an important instrument for a significant number of Queen's researchers," says Dr. Cole, who is also Queen's Deputy Provost.

    Tom Massey (Pharmacology and Toxicology) and Richard Oleschuk (Chemistry) were co-lead investigators with Dr. Cole on the grant proposal. All three will use the new machine with various projects.

    Dr. Cole researches drug resistance and how drugs are distributed within the body, focusing on what proteins are key to regulating those processes.

    "Two individuals can respond very differently to the same drug. We want to know how drugs interact with proteins that carry the drugs into and out of cells. These transporter proteins are much larger than the drugs they carry so we'd like to know where these drugs bind on the proteins - that's a key question we've been trying to address by other, non-direct methodologies. This new machine will allow us to obtain direct evidence that is extremely precise" says Dr. Cole.

    For more information, see the CFI website.

    2011 January 07

    The primary expectation of the successful appointee will be to develop an innovative research program in molecular pathology that will assist in the understanding of molecular and cellular aspects of cancer, leading to better diagnostic and therapeutic tools. {MORE]...

    2010 October 20

    The top 5 abstracts submitted by Junior Members of the College of American Patho logists (CAP) to the CAP'10 meeting were recognized during ceremonies held at the meeting. Second Place ($1,000 award): The Prognostic Value of MicroRNAs in Low-Risk Endom etrial Cancinomas. Jamie Snowdon, MD; Xiao Zhang, MSc; Victor Tron, MD; Tim Childs, PhD. [MORE]...

    2010 August 10
    Kingston, ON -- A team of Queen’s University researchers has received $450,000 to study a gene mutation common to breast cancer patients. The three-year funding supports research aimed at developing an inexpensive diagnostic tool for identifying individuals with the gene mutation.

    “In the long term, we hope to identify people early who are at risk of developing breast cancer – before they get cancer – so they have the best possible surveillance and treatment options,” says Scott Davey.

    The Canadian Breast Cancer Foundation funding will continue a collaborative project between Dr. Davey and Dr. Harriet Feilotter, both members of the Department of Pathology and Molecular Medicine and the Cancer Research Institute.

    The problem lies in BRCA1, a human tumor suppressor gene. Inheriting a damaged BRCA1 gene sets off a series of events that leads to an individual developing cancer. BRCA1 carriers develop tumors that present earlier and are more aggressive than other forms of breast cancer.

    “In the first phase of the study, we were able to detect changes in gene expression patterns that distinguish people with BRCA1 mutations from those with no apparent mutation," says Dr. Davey. "The second round of funding will allow us to validate and extend this work, hopefully leading to both a better understanding of BRCA1 function, and an improved method for identifying individuals that carry the gene mutations.”

    Using fresh blood cells from patients, the research team will try to nail down the actual function of BRCA1 to determine exactly how it inhibits cancer.

    2010 July 27
    A truly integrated approach to healthcare combines scientific research and clinical medicine to provide the best possible service for patients. Pathology and Molecular Medicine at Queen's has been a leader in adopting this model to meet healthcare needs in Kingston and throughout Southeastern Ontario.

    "The department is exceptional in that it sits at the interface between basic health science research and the clinical departments," says Vice-Dean, Research and Stauffer Professor of Basic Oncology Roger Deeley, who is also Vice President of Health Sciences Research at Kingston General Hospital (KGH).

    The department recognized this special role earlier than its counterparts elsewhere in Canada, and embraced it to a greater extent, so department members are now a mix of medical doctors and PhD researchers working together to meet broad healthcare needs.

    "There is no point in doing research if we can't turn it into something useful for the patient," says Victor Tron, head of Queen's Pathology and Molecular Medicine and KGH Laboratories. "We use our scientific and clinical research extensively with patients. It's an important part of the culture of our department."

    Faculty members play a vital role in clinical care by providing diagnostic laboratory services and engaging in direct patient care through integration with the KGH Clinical Laboratory Services Program.

    "A patient can't move through the health care system until they've been diagnosed, and that's where we come in," adds Dr. Tron. "We have ongoing collaboration with other physicians. They are the quarterbacks and we're the rest of the team in the background working together to serve the patient."

    They also deliver laboratory medicine services to hospitals throughout the region. Faculty members assist with blood work, cancer diagnoses, infectious disease diagnoses, and autopsies. They perform genetic testing and use their innovative laboratory research to help them achieve the most accurate diagnoses possible.

    And faculty members are active teachers at the university, bringing their collaborative approach into the classroom.

    "For example, if we're discussing a genetic disorder for skin cancer, I would talk about the clinical aspects of the disease and a biochemist would talk about the research aspect. It's a way for the students to see our collaborative process at work," says Dr. Tron.

    "I think it's a model that we should aspire to in other areas of health research," adds Dr. Deeley. "The fact that four pathology and molecular medicine faculty hold named research chairs speaks for itself."

    The department is home to over 50 Queen's scientists and clinical physicians as well as 15 cross-appointed professors. The researchers collaborate to produce world-renowned work focusing on everything from cytogenetics to infectious diseases to anatomic pathology, all with a single goal—improving patient outcomes.

    For more information on the Department of Pathology and Molecular Medicine, visit their new website at www.path.queensu.ca.

    2010 July 27
    Peter Greer (Pathology and Molecular Medicine) has received $1.6 million for two research projects aimed at developing new treatments to slow tumour growth in breast cancer.

    "We have been working on these projects for several years and are delighted that both grants were renewed in the last Canadian Institute for Health Research (CIHR) competition," says Dr. Greer.

    The researchers in Dr. Greer's lab are looking at the impact of two enzymes – Fer and calpain – on tumour growth.

    In previous studies at Queen's Cancer Research Institute, Dr. Greer and his research team have shown that inhibiting these enzymes slows cancer growth. Further research is aimed at a deeper understanding of how Fer and calpain contribute to causing tumours, and at developing new drugs to target the enzymes in cancer treatment.

    Fer regulates cellular functions by adding phosphates to proteins to affect their functions, and calpain regulates cell behaviour by splitting proteins into smaller peptides.

    "There are exciting new technologies and huge amounts of knowledge coming down the pipe that are revealing the biological complexities of cancer at a much more sophisticated level," says Dr. Greer. "I hope to see some of the work we have done contribute to that further understanding of cancer and to improved treatments for breast and other cancer in the future."

    Cancer is a disease of gene mutations. The challenge for cancer biologists is to determine how gene products, and in some cases mutant versions of them, interact in ways that control cancer cell survival and production, as well as migration and invasion properties leading to the spread of disease.

    2010 July 27
    Drs. James and Lillicrap presented and/or chaired five oral sessions involving the genetic analysis of inherited bleeding disorders, the use of animal models to evaluate clotting factor immunogenicity and the development of gene transfer strategies for hemophilia.

    In addition, several posters from the group were also displayed at the meeting, and Amrit Kahlon, a Queen's hematology fellow, attended the meeting to present her results on peri-operative levels of factor VIII and VWF.

    Finally, Dr. Lillicrap, a current member of the Medical Advisory Board of WFH, has been appointed as the Chair of the new Research Committee of the Federation, and there are plans to launch a new international inherited bleeding disorder research program at the 50th anniversary meeting of WFH in 2012.

    2010 July 7
    Three Pathology and Molecular Medicine residency trainees have been awarded prestigious PSI Foundation Research Prizes. 

    Dr Alanna Church’s examined the role of fibrosis as a prognostic factor in Hodgkin’s Disease.  Dr Church worked with Dr David Lebrun, a clinician scientist Anatomical Pathologist in the Department.

    Dr Jaime Snowdon used profiling of small non-coding RNA molecules, microRNAs, to examine their utility to diagnosis bladder cancer in the urine of patients at risk.  This work was lead by Dr Boag, the Service Chief of Anatomical Pathology at Queen’s.

    Finally, Dr Paul Masry implemented a novel cloning sequencing technique to profile a rare and poorly understood skin tumor called Merkel Cell Carcinoma.  The work was done under the supervision of Dr Victor Tron, Head of Pathology and Molecular Medicine at Queen’s University, in collaboration with Dr Tom Tuschl at Rockefeller University. 

    The residency program values and encourages resident research, and is very pleased that the above three physicians are being recognized for their valued contributions.

    Dr. Peter Greer and Dr. Susan Cole, both Professors in the Department of Pathology and Molecular Medicine, obtained new funding at the recent CIHR operating grant competition.

    2010 July 02
    Dr. Greer was impressive in obtaining two major five awards for a total of 1.6 million dollars.  One grant is focused on the calpain, a potential target in breast cancer.  While the second award, furthers Dr. Greer’s interest in the oncogene, fer.  Dr. Susan Cole was awarded 663K over five years to further her studies on the role of the transporter, ABCC4.