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Welcome to the Department
of Pathology and Molecular Medicine


boagI am delighted to have recently assumed the role of Head in the Department of Pathology and Molecular Medicine (DPMM) at Queen’s. This is an exciting time of growth and innovation in our Department which is uniquely placed at the interfaces between basic biomedical sciences, clinical laboratory services and the emerging field of personalized molecular medicine.

DPMM is home to many vibrant research programs with focussed areas of excellence including cancer biology and molecular hemostasis. We host the Queen’s Laboratory for Molecular Pathology core research facility and also the Canadian Cancer Trials Group tumour bank. The well established DPMM Graduate program offers Master’s and PhD degrees and a recently added a combined BScH/MSc degree that allows students to transition 4th year undergraduate research projects into accelerated Master’s degrees.

> continued (Welcome letter from Dr. Sandy Boag)


Spotlight

Banting Fellows and Vanier Scholars to attend the 68th Lindau Nobel Laureate meeting

Posted 2018 July 03


From: http://www.cihr-irsc.gc.ca/e/50989.html

Four outstanding CIHR supported researchers will be among the 400 aspiring young researchers from around the world who will spend a week with over 40 Nobel Laureates at the 68th Lindau Nobel Laureate meeting in Germany from June 24 - June 29, 2018. Participants will be able to exchange ideas, discuss projects and build international networks around this year's topics which will be dedicated to the field of chemistry. For young scientists standing at the beginning of their careers, it is a valuable opportunity to meet these undisputed role models and mentors, to seek their advice, to exchange thoughts and views, and to discuss current developments in science and beyond.

Our congratulations go to the four recipients nominated by CIHR who were accepted by the Lindau scientific review panel to attend this prestigious event: Mr. MohammadTaha MohammadiAzad (Vanier Canada Graduate Scholar), Mr. Michael Laffin (Vanier Canada Graduate Scholar), Dr. Brett Trost (Banting Postdoctoral Fellow) and Mr. Mark Wade (Banting Postdoctoral Fellow).

MohammadTaha MohammadiAzad

"For me this meeting is an enormous opportunity to take another step towards achieving my goals! I have a big dream to help people who suffer from cancer and to make this dream come true this meeting could help me a lot. These scientists didn't win the Nobel Prize overnight! They spent their entire life on it. I know they had down moments as well, but they never gave up! Sometimes I feel that my dream to cure cancer sounds too far away from reality but I keep trying and dreaming and hoping! For me, this meeting means a lot more than just visiting these great scientists as well as young researcher around the world. In fact, it starts a new chapter in my life, which is helping me to keep up on trying harder even if I fail hundred times! I have many questions to ask them about the journey that they have gone through so far, the uphills and the downhills, what made them more insistent in achieving their goals and how they coped with all the challenges they had faced!"

taha2018july

Mentoring Indigenous youth

Posted 2018 June 12


From: https://www.queensu.ca/gazette/stories/mentoring-indigenous-youth

First Nations students in grades 10 and 11 have deepened their knowledge of science and health care with the help of some Queen's graduate students.

The high-school students are participants in a pilot program aimed at giving them a leg up as they prepare for post-secondary studies. They met with their mentors from February through to the end of May.

"The vision of this program is to provide these students with a science-based education opportunity that leaves them feeling inspired, confident, and supported," says Lisa Doxtator, Aboriginal Community Outreach Liaison at Four Directions Aboriginal Student Centre and one of the program's co-ordinators.

"Our hope is that the students will consider furthering their education in the sciences and will be better established for postsecondary success through this program," adds Bruce Elliott, Professor Emeritus of the Department of Pathology and Molecular Medicine who is also one of the program's co-ordinators. "The Four Directions Centre provides an ideal supportive home for our program."

Working alongside Dr. Elliott and Ms. Doxtator are assistant co-ordinators, PhD student Chelsea Jackson and MSc graduate Sarah Nersesian; and graduate student mentors Nicole Morse, Natasha Vitkin, and Matteo Zago-Schmitt of the Queen's Collaborative Cancer Grad Program and the Department of Pathology and Molecular Medicine.

mentor2018june

Royal College Exam

Posted 2018 June 08


Congratulations to our senior residents: Nikoo Parvinnejad, Amanda Xu and Kevin Ren have passed the Anatomical Pathology Royal College Exam!!!

royal2018june

[see more Spotlight Archive]...

QLMP

Welcome to the Queen's Laboratory for Molecular Pathology
The QLMP is part of the Department of Pathology and Molecular Medicine at Queen's University, Kingston, Ontario. The QLMP provides rapid and economic advanced pathology services to researchers, students, clinicians, and private sector groups. The QLMP promotes productive interactions between scientists, clinicians, pathologists, and others by supporting research projects of common interest.
The QLMP offers a wide array of services including:
  • Histology
  • TMA design and construction
  • Whole slide scanning
  • TMA scanning
  • Customized immunohistochemistry and immunofluoroscence
  • Image analysis tools
  • Secure web database access and storage
  • Plastination
  • Electron Microscopy

    EVENTS

    events

    Wednesday July 18
    8:00-8:55 Slide Review for Royal College Exam - Richardson Lab Rm. 102 - Dr. K. Song
    9:00-9:55 Micro Round - Multihead Microscope Rm. - Dr. D. Berman
    10:00-10:55 Learning and Teaching Plan Presentations - Richardson Lab Rm. 102 - Drs. M. Xu and M. Chen
    11:00-11:55 Autopsy Orientation Continued with Dr. J. Tanguay - Autopsy Conference Rm. Mandatory for CBME residents (year 1 & 2). All are welcome.

    Thursday July 19
    11:30-12:30 Grand Round Cancelled - Summer Break
    2:00-3:00 Special Seminar - Botterell Hall, Room B139 - Dr. Michael Witcher Departments of Oncology and Experimental Medicine McGill University The Lady Davis Institute and Segal Cancer Centre of The Jewish General Hospital "Targeting novel chromatin-related processes in breast cancer" Summary: CTCF is a haploinsufficient tumor suppressor that regulates expression of oncogenes and tumor suppressors. We recently showed that CTCF also promotes repair of DNA double strand breaks through recruitment of BRCA2. CTCF is targeted for deletion or mutation in a spectrum of cancers, including 50% of breast tumors and 18% of endometrial cancers. These events are likely important drivers of tumor progression, however, their functional impact remain obscure. Using CRISPR/Cas9 to introduce copy number loss or cancer-specific CTCF mutations into normal epithelial cells, we find that CTCF dysfunction promotes cell invasion and increased mammosphere volume. Using RNA-seq and ChIP-seq approaches we have identified oncogenic pathways normally suppressed by CTCF. We, and others, previously reported that modification of CTCF by poly (ADP-ribosylation), known as PARylation, is often lost in breast cancer. We now show that the enzyme responsible for removing PARYlation, PARG, is commonly overexpressed in cancer and acts as an oncogene, promoting tumor outgrowth and metastasis. Importantly, we demonstrate that PARG is a potent therapeutic target and using chemical screens, we have identified novel small molecule inhibitors of PARG, acting in the nanomolar range, that we are now testing for anti-cancer activity.

    Friday July 20
    9:00-9:30 Gross Rounds - Gross Room - Dr. M. Khara
    1:30-2:30 Hematopathology Morphology Round - Autopsy Conference Rm.


    Thursday 2018 September 06 - Fall Term Undergrad Classes begin

    Wednesday 2018 September 19 - Last date to drop fall term classes without financial penalty

    Thu-Fri 2018 October 25-26 - Fall mid-term break - no classes

    Friday 2018 November 02 - Last date to drop fall term classes without academic penalty

    Friday 2018 November 30 - Fall Term Classes end

    Friday 2018 December 21 - Last day of exams

    Monday 2019 January 07 - Winter term classes begin

    Friday 2019 January 19 - Last date to drop winter term classes without financial penalty

    Tue-Fri 2019 February 19-22 - Winter midterm Reading Week

    Friday 2019 April 05 - Winter Term Classes end


    See the Queen's University Events Calendar here

    Courses offered in 2018 September: CANC499 * PATH425 * PATH499 * PATH823

    Courses offered in 2019 January: CANC440 * PATH310 * PATH430/826


    Announcements / Notices

    2018 June 28
    Welcome to the Department Dr. Yun Huang, Clinical Biochemist and Dr. Tao Wang, Pathologist, as of 2018 July 03.

    Wednesday 2018 May 23
    Effective 2018 June 01, Dr. Michael Chan will assume the role of Service Chief, Clinical Chemistry
    Effective 2018 July 01, Dr. Susan Crocker will continue with a 3 year additional term as Clinical Director, Cytogenetics.
    Also effective 2018 July 01, Dr. David Good will continue his role as Service Chief, Division of Hematopathology for a 3 year additional term.

    Job Opportunities

    Translational Surgical Pathology/Chemistry Scientist
    The Departments of Pathology and Molecular Medicine, Surgery, and Chemistry at Queen’s University invite applications from internationally recognized scientists whose research is congruent with the objective of building an outstanding program in innovative translational research linking analytical chemistry, diagnostic pathology and advanced surgical practice. The successful applicant will have a tenured appointment at the rank of full Professor and is expected to participate in undergraduate education and supervise both graduate students and postdoctoral fellows. Salary will be commensurate with qualifications and experience. The preferred start date for this position is January 1, 2019.
    Posted 2018 May 28
    Complete information here

    Tier I Canada Research Chair in Bioinformatics
    Faculty of Health Sciences and Department of Pathology and Molecular Medicine Queen’s University, Kingston, Ontario, Canada The Faculty of Health Sciences (https://healthsci.queensu.ca/) and the Department of Pathology and Molecular Medicine at Queen’s University are seeking an international leader and innovator in the areas of bioinformatics and health analytics. Applicants should have an established research program focused on precision medicine, particularly in relation to the identification of cancer diagnostic and prognostic markers and potential therapeutic targets. The successful candidate will become the designated nominee for an approved Tier I Canada Research Chair (http://www.chairs-chaires.gc.ca/program-programme/index-eng.aspx). This is a tenured appointment at the level of Professor.
    Posted 2018 Feb 15
    Complete information here


    NIBDGL

    Welcome to The Canadian National Inherited Bleeding Disorder Genotyping Laboratory Providing molecular diagnostic services to the Canadian inherited bleeding disorder community.
  • Page Last Updated: 2018 June 21