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RESEARCH OVERVIEW
“Structure/function studies of ABC transporters”
ABC transporters use the energy of ATP hydrolysis to transport substrates ranging from ions and small molecule drugs to large polypeptides, across cellular membranes. Several ABC proteins have been implicated in the multidrug resistance of various forms of cancer, as well as a number of inherited disorders, such as cystic fibrosis and Tangier disease, a severe disorder of cholesterol metabolism. Our research involves a range of studies of the structure, mechanism of action and subcellular trafficking of several members of the Multidrug Resistance Protein (MRP/ABCC) subfamily ‘C’ of ABC transporters, as well as, ABCA1, which is defective in Tangier disease. |
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