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RESEARCH OVERVIEW
“Elucidating the pathobiology of lymphoid neoplasms”
Our basic research on lymphoid neoplasms seeks to understand molecular mechanisms by which oncogenic transcription factors, primarily a chimeric protein called E2A-PBX1, contribute to acute lymphoblastic leukemia. Methods include protein binding assays, chromatin immunoprecipitation, gene transfer using retroviral vectors, flow cytometry and hematopoietic stem cell transplantation. Our translational research involves the identification of biomarkers in malignant lymphoma, primarily through determinations of protein expression or molecular alterations in biopsy samples. We make extensive use of quantitative, multiplex immunofluorescence data analyzed in a cell compartment-selective manner using AQUA software and correlated with conventional pathological and clinical variables. |
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