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RESEARCH OVERVIEW
“Molecular studies of hemostasis”
The studies in this laboratory are all focused on the contributions to blood clotting made by the two proteins, factor VIII and von Willebrand factor. Inherited deficiencies or dysfunction of these proteins result in the two most common familial bleeding disorders, hemophilia A and von Willebrand disease. We have three areas of research activity: the evaluation of factor VIII gene transfer as a therapeutic option for hemophilia A; the immune response to factor VIII, and a molecular characterization of the biology and pathobiology of von Willebrand factor. The research approaches utilized in these studies comprise molecular and cell biology, molecular genetics, animal models of disease, and human population studies.
Christine Hough, PhD (Research Associate – Adjunct professor) |
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