Physiology and Pathobiology of von Willebrand Factor

Project Aims1.

1. To determine the genetic causes of von Willebrand disease.

2. 1.To investigate the influences and effects of:
a)  VWF cleavage by ADAMTS13
b)  VWF binding to platelet GpIb

3.3. To develop approaches to quantify clinically significant bleeding
and to determine the genetic influences on bleeding.

4. To develop novel molecular therapies for VWD.

von Willebrand Factor Pathobiology


Mutations Causing Type 1 von Willebrand Disease in Canada



Recombinant von Willebrand Factor Variants

Bleeding Scores in von Willebrand Disease



SPECIFIC AREAS OF RESEARCH ACTIVITY
Physiology and
Pathobiology of
von Willebrand Factor
The
Immunology
of Factor VIII
Gene Transfer
Approaches
for Hemophilia A